What Causes Depression?
Depression is a complex condition with many potential triggers, and it’s different for everyone. However, people who undergo a traumatic life event are more likely to develop it. Here are some common depression causes.
- Brain chemistry. An imbalance in neurotransmitters like dopamine and serotonin can affect mood regulation. For instance, low levels of serotonin may lead to feelings of sadness (a common symptom of depression). Besides, the brain’s ability to change and adapt can be affected by varying experiences and stress, contributing to depression.
- Genetic factors. If depression runs in your family, you might be more prone to it. For example, having a parent or a sibling with depression increases your risk of developing it.
- Traumatic events. Losing a loved one to death, physical or emotional abuse or a severe accident can also lead to depression. A study shows that experiencing natural disasters may result in depression and other mental health conditions.
- Hormonal changes may also trigger depression. This is common during pregnancy, puberty, postpartum, and menopause. Postpartum depression, for instance, affects 1 in 7 women due to drastic shifts in hormones.
- Chronic illness. Living with a chronic illness like heart disease or cancer can take a toll on mental well-being. For example, according to the Arthritis Foundation, depression frequently goes “hand in hand” with arthritis. The constant fatigue and pain can contribute to feelings of sadness.
- Social isolation. Loneliness and a lack of social support could be another reason. Elderly individuals who live alone are at higher risk of depression.
- Major life changes. Even positive changes, like moving to a new city or starting a new job, can cause stress and potentially lead to depression. The pressure and adjustment period of starting something new can trigger depressive symptoms.
- Environmental factors. Constant stress from a demanding job or being unemployed can also lead to depression. Besides, people living in urban areas have higher depression rates due to noise, crowding, and pollution.
- Diet and nutrition. Nutrient deficiency can also contribute to depression. For instance, a lack of essential nutrients such as omega-3 fatty acids, vitamins (B12 and D), and minerals (magnesium) may contribute to depression.
- Sleep disorders. Problems like sleep apnea and insomnia can increase the risk of depression. Sleep issues affect the function of serotonin, which may exacerbate existing symptoms or directly contribute to the condition.
Disorders that May Trigger Depression
Depression can sometimes be a symptom of other mental health disorders. These may include but aren’t limited to the following.
- Cyclothymic disorder. This condition features milder but disruptive mood swings. The highs and lows are less extreme. However, they still significantly impact daily life.
- Bipolar I and II disorders involve extreme mood swings. Individuals may experience manic highs and depressive lows. Distinguishing between bipolar disorder and unipolar depression can be challenging because depressive episodes can look very similar.
- Persistent Depressive Disorder, also called Dysthymia, is a long-term form of depression. It is less severe than major depressive disorder but lasts for years. People experiencing this condition may struggle to function normally or enjoy daily activities.
- Disruptive Mood Dysregulation Disorder (DMDD). Found in children, DMDD is characterized by severe irritability and intense temper outbursts. As these children grow older, they are at risk of developing depression or anxiety disorders.
- Premenstrual dysphoric disorder. This involves severe depression symptoms that correlate with hormonal changes around the menstrual cycle. Symptoms typically start a week before the period and ease within a day or two after it begins.
Depression Risk Factors

Depression can affect anyone. However, certain factors increase the risk of developing this condition.
- Substance abuse. Alcohol or drug abuse can lead to or worsen depression. People who abuse alcohol, for instance, might experience exacerbated depressive symptoms because it leads to chemical changes in the brain. Studies show that one-third of people with depression also have alcohol usage problems.
- Personality. People with certain personality types might be at risk of developing depression. Highly emotional people and introverts are thought to experience negative thoughts, which may eventually lead to depression.
- Certain medications. Some drugs have side effects that can increase the risk of depression. These include beta-blockers, ACE (Angiotensin-converting enzyme) inhibitors, stimulants, and others.
- Gender. Women are more likely to experience depression, possibly due to hormonal differences and life circumstances. For example, women may experience depression during hormonal changes that occur in pregnancy or menopause.
- Early childhood trauma. Severe stress in childhood can increase the risk of depression later in life. Children who lose a parent at a young age might be more susceptible to depression as they grow older.
Recognizing these risk factors is crucial in providing timely support for those who may be more vulnerable to depression. This way, we can better empathize with and assist those in need.
Depression Diagnosis
Diagnosing depression involves a thorough evaluation by a healthcare professional. They may use a combination of the following methods.
Clinical Interview
A mental health professional might ask detailed questions about your symptoms, medical history, and family history.
This will help them inquire about your behavior and how it affects your daily life. For example, they might ask how long you’ve been feeling sad or if you’ve lost interest in activities you once enjoyed.
Diagnostic Criteria
Your healthcare provider may compare your symptoms to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). The DSM-5 outlines specific symptoms and duration requirements. For instance, it helps identify if you’re experiencing at least 5 symptoms for around 2 weeks.
Some common depressive symptoms it highlights include the following.
- Loss of interest
- Weight gain or loss
- Fatigue
- Insomnia
- Reduced concentration
- Agitation
- Feeling worthless
- Fatigue
- Thoughts of suicide.
- Depressed mood
Physical Examination
In some cases, a physical exam can help rule out other health conditions that may cause similar symptoms. For instance, thyroid problems or vitamin deficiencies can sometimes mimic depression. However, these conditions alone do not confirm depression. A doctor may use additional criteria for accurate diagnosis.
Questionnaires and Rating Scales
Standardized questionnaires like the Beck Depression Inventory (BDI) or the Patient Health Questionnaire-9 are available to diagnose depression. These tools ask about the frequency and intensity of symptoms. This provides a structured way to gauge the impact of depression on your life.
Psychiatric Evaluation
A psychiatric evaluation involves talking to a psychologist or a psychiatrist. They encourage you to talk about your thoughts and feelings. This helps them identify the underlying issues that could contribute to depression.
Conclusion
Life’s struggles can sometimes lead to mental strain. When this strain turns into persistent feelings of sadness, it’s essential to understand what might be causing them. Depression can result from several factors, and accurate diagnosis is key to managing the symptoms.
When healthcare providers understand the precise cause behind someone’s depression, they tailor their treatments to address the root issue. This compassionate approach encourages individuals to reclaim their joy and resilience.
FAQs
Q1. Which Diseases Are Caused By Depression?
Depression can contribute to various physical health problems like chronic pain, diabetes, and heart disease. It may also worsen conditions like anxiety and other mental health disorders.
Q2. How Does Depression Affect the Brain?
Depression can lead to changes in brain structure and function. Gradually, it affects areas involved in mood regulation and memory. This often results in reduced levels of certain neurotransmitters like dopamine and serotonin.
Q3. What Is the Main Reason for Depression?
A single reason isn’t responsible for depression. In fact, it is caused by a combination of genetic, psychological, and environmental factors. Besides, stressful life events like the loss of a loved one or trauma can also trigger depression.
